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Professor, Pathology and Immunology Ladenson Professor, Pathology and Immunology Surgical Pathologist-in-Chief, Barnes-Jewish Hospital 3rd Floor, Peters Building Office: (314) 362-0112 E-mail: humphrey@wustl.edu Pub Med Search

Research

The primary focus of my research is on urologic malignancies in general and specifically on prostate adenocarcinoma. At the clinicopathologic level, investigations on the surgical pathology of the prostate gland are performed including morphometric analysis of prostate cancer, studies on prostatic intraepithelial neoplasia, a putative precancerous proliferation, and morphologic studies on prostate-specific antigen-detected prostate cancer. Gene discovery and marker discovery in potential prostate cancer precursors and prostatic carcinoma variants are being pursued via gene expression profiling, coupled with expression validation. Research also is in progress on the role of growth factors and their receptors in biologic behaviors of prostatic carcinoma. The specific growth factor that is currently being studied is hepatocyte growth factor/scatter factor (HGF/SF), which is a heterodimeric 92 kilodalton protein that is capable of influencing epithelial cell growth motility and invasiveness. The receptor for HGF/SF is the c-met proto-oncogene, which is tumorigenic in transfection studies. We have been studying the expression of HGF/SF and c-met in human prostatic tissues and cell lines by polymerase chain reaction (PCR), Northern and Western blotting, in situ hybridization and immunohistochemistry. We are utilizing in vitro and in vivo models to define the biologic effects of overexpressed c-met in both benign and malignant prostate epithelial cells. Studies have also been published on HGF/SF as a serum marker and therapeutic target for prostate cancer. It is anticipated that these investigators will provide insight into the role of this growth factor and its oncoprotein receptor in the growth of prostate cancer, which is now the most common malignancy in American men.

Editorial Responsibilities
	Present	Associate Editor	American Journal of Clinical Pathology
	Present	Member, Editorial Board	The American Journal of Surgical Pathology
	Present	Member, Editorial Board	Modern Pathology

Service to the Department
	Present	Chief of Anatomic & Molecular Pathology
	Present	Member, Resident Selection Committee

Service to the University
	Present	Medical Student (2nd Year) Lectures on prostate cancer, bladder diseases, testis diseases
	Present	Member, Hospital Medical Staff Performance Improvement Oversight Committee
	Present	Member, Medical School Faculty Rights Committee

Diagnostic Expertise
	Urological pathology, especially urological malignancies, including prostate cancer, bladder cancer, kidney cancer, and testis cancer

Clinical Interest
	Anatomic and Molecular Pathology - Molecular Pathology
	Anatomic and Molecular Pathology - Urologic Pathology

Selected Publications
	Wild PJ, Giedl J, Stoehr R, Junker K, Boehm S, van Oers JMM, Zwartoff EC, Blaszyk H, Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI, Hartmann A. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. J Pathol. 2007 Jan;(1)211:18-25, 2007 Abstract
	Turbiner J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishanan A, Oliva, E. Cystic nephroma and mixed epithelial and stromal tumor of kidney : A detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol. 2007 Apr;31(4):489-500, 2007 Abstract
	Humphrey PA. Diagnosis of adenocarcinoma in prostate needle biopsy tissue. J Clin Pathol 60:34-42, 2007 Abstract
	Humphrey PA, Halabi S, Picus J, Sanford B, Vogelzang NJ, Small EJ, Kantoff PW. Prognostic significance of plasma scatter factor/hepatocyte growth factor levels in patients with metastatic hormone-refractory prostate cancer : Results from Cancer and Leukemia Group B 150005/9480. Clin Genitourinary Cancer 4 : 269-274, 2006 Abstract
	Gokden N, Roehl KA, Catalona W, Humphrey PA. High-grade prostatic intraepithelial neoplasia in needle biopsy as a risk factor for detection of adenocarcinoma : Current level of risk in a screening population. Urology 65:538-542, 2005 Abstract
	Humphrey PA. Gleason grading and prognostic factors in carcinoma of the prostate. Mod Pathol 17:292-306, 2004 Abstract
	Thorson P, Swanson P, Vollmer RT, Humphrey PA. Basal cell hyperplasia in the peripheral zone of the prostate. Mod Pathol 16:598-606, 2003 Abstract
	Bismar TA, Lewis JS Jr., Vollmer RT, Humphrey PA. Multiple measures of carcinoma extent versus perineural invasion in prostate needle bipsy tissue in prediction of pathologic stage in a screening population.. Am J Surg Pathol 27:432-440, 2003 Abstract
	Hu Y, Ippolito JE, Garabedian EM, Humphrey PA, Gordon JI. Molecular characterization of a metastatic neuroendocrine cancer arising in the prostates of transgenic mice.. J Biol Chem 227:44462-44474, 2002 Abstract
	Vollmer RT, Humphrey PA. The relative importance of anatomic and PSA factors to outcomes after radical prostatectomy for prostate cancer.. Am J Clin Pathol 116:864-870, 2001 Abstract
	Naughton M, Picus J, Zhu X, Catalona WJ, Vollmer RT, Humphrey PA.. Scatter factor/hepatocyte growth factor elevation in the serum of prostate cancer patients.. J Urol 165:1325-1328, 2001 Abstract
	Abdulkadir SA, Qu Z, Garabedian E, Song SK, Peters TJ, Svaren J, Carbone JM, Naughton CK, Catalona W. Impaired prostate tumorigenesis in Egr-1 deficient mice.. Nature Med 7:101-107, 2001 Abstract
	Gokden N, Nappi O, Swanson PE, Pfeifer JD, Vollmer RT, Wick MR, Humphrey PA. Renal cell carcinoma with rhabdoid features. Am J Surg Pathol 24:1329-1338, 2000 Abstract
	Garabedian EM, Humphrey PA, Gordon JI. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells. Proc Natl Acad Sci 95:15382-15387, 1998 Abstract
	Humphrey PA, Kaleem Z, Swanson PE, Vollmer RT. Pseudohyperplastic prostatic adenocarcinoma. Am J Surg Pathol 22:1239-1246, 1998 Abstract