SITE SEARCH

Assistant Professor, Pathology and Immunology Peters Building, 3rd Floor, Room 300F Office: (314) 362-0346 E-mail: fkreisel@wustl.edu Pub Med Search

Research

My work so far has focused on the developmental origin of "plasmacytoid" dendritic cells (pDC) where under the mentorship of Dr. Marco Colonna I have investigated the capacity of different murine bone marrow subsets to acquire morphologic, immunophenotypic, and functional characteristics of pDCs after in vitro activation with Flt-3-L. The developmental origin of the different subsets of dendritic cells (DC), specifically pDCs or interferon-producing cells (IPC) has been unclear for many years. Whereas "myeloid" DC or "conventional" DC (cDC) can be efficiently generated from myeloid progenitors, PDC were initially believed to be of lymphoid origin due the expression of molecular programs associated with early lymphoid development. More recent studies indicate that common progenitors of both myeloid and lymphoid restricted potential can give rise to cDC and pDC, contradicting earlier studies suggesting that different subsets of DC arise from distinct pools of lineage-restricted precursors. Furthermore, in a collaborative effort with the Division of Cardiothoracic Surgery, we are studying the role of pDC in induction and maintenance of immune tolerance to alloantigen. It has been shown in mouse models that intratracheal administration of fully MHC mismatched splenocytes in multiple strain combinations leads to prolongation of cardiac allograft survival. Since mouse lung consistently contains a population of resident pDC, we hypothesize that the lung resident pDC are important mediators of intratracheal mucosal tolerance. In collaboration with Dr. G. Alexander Patterson from the division of Cardiothoracic Surgery, this research proposal was awarded the 2005 ASTS-Wyeth Collaborative Scientist Research Award.

Service to the Department
	" - Present	Medical Student Teaching in the Undergraduate Medical Curriculum

Diagnostic Expertise
	Hematopathology

Clinical Interest
	Anatomic and Molecular Pathology - Hematopathology

Selected Publications
	Krupnick AS, Gelman AE, Barchet W, Richardson S, Kreisel FH, Turka LA, Colonna M, Patterson GA, Krei. Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells. J Immunol. 2005 Nov 15;175(10):6265-70, 2005 Abstract
	Kreisel D, Pasque MK, Damiano RJ Jr, Medoff G, Kates A, Kreisel FH, Lawton JS. Bartonella species-induced prosthetic valve endocarditis associated with rapid progression of valvular stenosis. J Thorac Cardiovasc Surg. 2005 Aug;130(2):567-8, 2005 Abstract
	H. Luo, Q. Li, J. O'Neal, F. Kreisel, M. M. Le Beau, M. H. Tomasson. C-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated anti-apoptotic mutations. 2005 Oct 1;106(7):2452-61. Epub 2005 Jun 21, 2005 Abstract
	A. Castellano-Sanchez and F. H. C. Kreisel. Pathology quiz case: a 39-year-old man with severe lower back pain. Plasma cell leukemia. 2005 Arch. Pathol. Lab. Med. 129(3):e70-2, 2005 Abstract
	S. Krupnick, J.V. Lombardi, F. H. Engels, D. Kreisel, H. Zhuang, A. Alavi, J.P. Carpeneter. 18-Fluorodeoxyglucose Positron Emission Tomography as a novel imaging tool for the diagnosis of aortoenteric fistula and aortic graft infection. a case report. 2003 Vasc. Endovascular Surg. 37 (5): 363-366, 2003
	D. Kreisel, A. S. Krupnick, A. E. Gelman, F. H. Engels, S. H. Popma, A. M. Krasinskas, K. R. Balsara. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of allorecognition. Nature Medicine 8: 233-239, 2002
	M. Paessler, F. H. Kreisel, V. A. LiVolsi, L. A. Akslen, Z. W. Baloch. "Can we rely on pathologic parameters to define conservative treatment of papillary thyroid carcinoma.". Internat. J. Surg. Path. 10: 267-272, 2002
	M. B. Faries, I. Bedrosian, S. Xu, J. Roros, M. A. Moise, H. Q. Nguyen, F. Engels, B. J. Czerniecki. Calcium signaling inhibits IL-12 production and activates CD83+ dendritic cells that induce Th2 cell development. Blood 98: 2489-2497, 2001
	F. Engels, D. Kreisel, I. Bedrosian, G. Koski, M. Faries, P Cohen, B. Czerniecki. Calcium signaling induces acquisition of dendritic cell characteristics in chronic myelogenous leukemia myeloid progenitors. Proc. Natl. Acad. Sci. USA 96: 10332-10337, 1999
	G. Koski, G. Schwartz, D. Weng, R. Gress, F. Engels, M. Toskos, B. J. Czerniecki, P. A. Cohen. Calcium ionophore-treated myeloid cells acquire many dendritic cell characteristics independent of prior differentiation state, transformation status or sensitivity to biologic agents. Blood 94: 1359-1371, 1999