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Faculty > Faculty Alphabetical > Jack Ladenson, PhDOree M. Carroll and Lillian B. Ladenson Professor, Clinical Chemistry
Co-Medical Director, Clinical Chemistry
4320 Forest Park Blvd., Cortex Building, Room 207
Office: (314) 454-8436
E-mail: ladenson@wustl.edu
Web-site: size=50
Pub Med Search |  |
Research
| | My laboratory is interested in the development of rapid, accurate techniques for the diagnosis of human disease. More specifically the work involves the development and use of antibodies suitable for basic or clinical research or diagnostic tests. Most of our work has concerned the diagnosis of myocardial infarction (MI). A monoclonal antibody specific to the creatine kinase-MB (CK-MB) isoenzyme has been developed which does not react with CK-BB, CK-MM or mitochondrial CK. This antibody is now widely utilized in commercially available assays. Our work has been extended to the development of widely utilized assays for Troponin I and myoglobin.
Our current work involves the development of assays to improve the diagnosis of brain injury, both acute and chronic. In addition, an effort to develop molecular biology approaches to the development of monoclonal antibodies without the need to fuse with hybridoma cells is being explored. This type of approach should extend greatly the ease of making monoclonal antibodies and the development of antibodies to subtle structural differences.
For the last ten years, I have run the clinical pathology programs for Pathologists Overseas, an organization whose mission is to help improve and provide affordable pathology and clinical laboratory services to under-served patients worldwide. This has lead to a variety of short-term projects, as well as long-term projects in the countries of Eritrea and Bhutan. These efforts, sustained by volunteers, have the goal of upgrading laboratory services, upgrading the training of laboratory personnel, extending laboratory testing to regional hospitals, and helping to develop a standardized national laboratory system. |
Service to the Department
| | 2003 - 2008 | Interim Director, Division of Laboratory Medicine |
Diagnostic Expertise
| | Clinical Chemistry | | Biomarkers | | Laboratory Medicine in developing countries |
Clinical Interest
| | Laboratory and Genomic Medicine - Clinical Chemistry |
Selected Publications
| | Lee JM, Blennow K, Andreasen N, Laterza O, Modur V, Olander J, Gao F, Ohlendorf M, Ladenson JH. The brain injury VLP-1 is increased in the cerebrospinal fluid of Alzheimer. Clin Chem 54:1617-1623, 2008 Abstract
| | Ladenson JH. A personal history of markers of myocyte injury [myocardial infarction]. Clinica Chimica Acta 381(1):3-8, 2007 Abstract
| | Scott MG, Morin S, Hock KG, Seyoum M, Ladenson JH. Establishing a simple and sustainable quality assurance program and clinical chemistry services in Eritrea. Clin Chem 53(11):1945-1953, 2007 Abstract
| | Windus DW, Ladenson JH, Merrins CK, Seyoum M, Windus D, Morin S, et al. Impact of a multidisciplinary intervention for diabetes in Eritrea. Clin Chem 53(11):1954-1959, 2007 Abstract
| | Laterza OF, Modur VR, Crimmins DL, Olander JV, Landt Y, Lee JM, Ladenson JH. Identification of novel brain biomarkers. Clin Chem: 52:1713-1721, 2006 Abstract
| | Ladenson RC, Crimmins DL, Landt Y, Ladenson JH. Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment. Anal Chem 78:4501-4508, 2006 Abstract
| | Rosalki SB, Roberts R, Katus HA, Giannitsis E, Ladenson JH. Cardiac biomarkers for detection of myocardial infarction: Perspectives from past to present. Clin Chem 50:2205-2213, 2004 Abstract
| | Ladenson JH, Scott MG, Klarkowski D, Seyoum M. The Use of a Major Medical Center Clinical Laboratory as a Reference Laboratory for a Developing Country. Clin Chem 49:162-166, 2003 Abstract
| | Chi XS, Landt Y, Crimmins DL, Dieckgraefe BK, Ladenson JH. Isolation and characterization of rabbit single chain antibodies to human Reg lá Protein. J Immunol Methods 266:197-207, 2002 Abstract
| | Adams III, JE, Bodor GS, Dāvila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. Cardiac troponin-I: a marker with high specificity for cardiac injury. Circulation 88:101-10, 1993 Abstract
| | Bodor GS, Porter S, Landt Y, Ladenson JH. Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction. Clin Chem 38:2203-2214, 1992 Abstract
| | Silva DP, Landt Y, Porter SE, Ladenson JH. Development and application of monoclonal antibodies to human cardiac myoglobin in a rapid fluorescence immunoassay. Clin Chem 37:1356-1364, 1991 Abstract
| | Vaidya HC, Maynard Y, Ladenson JH. Direct measurement of creatine kinase-MB activity in serum after extraction with a monoclonal antibody specific to the MB isoenzyme. Clin Chem 32:657-663, 1986 Abstract
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Current Trainees
| | Christina Lockwood, PhD |
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