SITE SEARCH

Assistant Professor, Pathology and Immunology Assistant Professor, Otolaryngology Suite B - 2nd Floor Kingshighway Bldg - North Campus; Suite 2303 Office: (314) 362-7753 E-mail: jlewis@path.wustl.edu Web-site: size=50

Research

My major interest is on squamous cell carcinoma of the head and neck and its variants. 1) Oropharyngeal carcinoma. I study human papilloma virus (HPV)-related oropharyngeal carcinomas, specifically their immunohistochemical characteristics, molecular characteristics, and morphology. We look at how all of these features correlate with tumor behavior and patient outcome. I also study variants of squamous carcinoma such as basaloid, undifferentiated, etc., and their relationship with HPV. 2) Perineural invasion. I study both its mechanisms and determinants with the hope of identifying novel markers for both diagnostic, treatment, and prognostic uses. 3) Laryngeal carcinoma. I am early into a study of high stage tumors to investigate markers of treatment response to either primary radiation or surgery. I also have other projects studying high grade neuroendocrine carcinomas and frozen section methods/improvement. Finally, I also collaborate with several members of the Department of Otolaryngology and Head and Neck Surgery and of Radiation Oncology on other aspects of head and neck pathology, radiology, and tumor biology.

Editorial Responsibilities
	2008 - Present	Reviewer and Editorial Board Member	Head and Neck Pathology
	2008 - Present	Reviewer	Human Pathology
	2008 - Present	Reviewer	Cancer
	2007 - Present	Reviewer	Archives of Otolaryngology - Head and Neck Surgery

Service to the Department
	2007 - Present	Director, Histology and Tissue Microarray Components of AMP Core Research Laboratory
	2006 - Present	Assistant Director, Anatomic Pathology Clinical Immunohistochemistry Laboratory

Service to the University
	2005 - Present	Lecturer for 2nd Year Medical Student Pathology Course - Pathology of the Esophagus and Small Intestine
	2005 - Present	Laboratory Coordinator and Instructor: Gross Pathology of the Gastrointestinal Tract

Diagnostic Expertise
	Head and Neck Pathology, General Surgical Pathology

Clinical Interest
	Anatomic and Molecular Pathology - Head and Neck Pathology
	Anatomic and Molecular Pathology - General Surgical Pathology

Selected Publications
	Chernock RD, Pfeifer J, Holden J, Lewis JS Jr.. Receptor tyrosine kinases in sinonasal undifferentiated carcinomas – Evaluation for EGFR, c-kit, and her2/neu expression.. Head and Neck 31(7); 919-927, 2009 Abstract
	Rich JT, Milov S, Lewis JS Jr, Thorstad WL, Adkins DR, Haughey BH. Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors.. Laryngoscope (Epub), 2009 Abstract
	Chernock RD, El-Mofty SK, Thorstad W, Parvin C, Lewis JS Jr.. HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx. Utility of microscopic features in predicting patient outcome.. Head and Neck Pathology (Epub), 2009
	Uppaluri R, Dunn GP, Lewis JS Jr.. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers.. Cancer Immunity 8:16., 2008 Abstract
	Lewis JS Jr.. Spindle cell lesions – neoplastic or non-neoplastic? Spindle cell carcinoma and other atypical spindle cell lesions of the head and neck.. Head and Neck Pathology 2(2): 103-110., 2008
	Serrano MF, El-Mofty SK, Gnepp DR, Lewis JS Jr. Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Human Pathology 39(4): 591-598, 2008 Abstract
	Dunn GP, Lewis JS Jr, Sunwoo JB, Uppaluri R. Spontaneous regression of cutaneous head and neck melanoma: Implications for the immunologic control of neoplasia. Head and Neck 30(2): 267-272, 2007 Abstract
	Kozower BD, Javiden-Nejad C, Lewis JS Jr, Safdar S, Cooper JD, Patterson GA. Clinical-pathologic conference in general thoracic surgery: malignant transformation of recurrent respiratory papillomatosis. J Thor and Cardiovasc Surg 130(4): 1190-1193, 2005 Abstract
	Lewis JS, El-Mofty SK, Ritter JH. Alternative epithelial markers in sarcomatoid carcinomas of the head and neck, lung, and bladder – p63, MOC-31, and TTF-1. Modern Pathology 18: 1471-1481, 2005 Abstract
	Bismar TA, Lewis JS, Vollmer RT, Humphrey PA. Multiple measures of carcinoma extent versus perineural invasion in prostate needle biopsy tissue in prediction of pathologic stage in a screening population. Am J Surg Pathol 27:432-440, 2003 Abstract
	Lewis JS, Vollmer RT, Humphrey PA. Prostate needle biopsy carcinoma extent in the prediction of whole gland tumor volume in a screening population. Am J Clin Pathol 118:442-450, 2002 Abstract
	. . ,