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Assistant Professor, Pathology and Immunology Assistant Director, Pathology and Immunology Office: 454-8472 Lab: 454-5975 E-mail: NOVACK@WUSTL.EDU Web-site: http://bmd.im.wustl.edu/faculty/novack.html

DBBS Graduate Program Affiliation
	Molecular and Cellular Biology

Diagnostic Expertise
	metabolic bone biopsy
	breast pathology

Clinical Interest
	Anatomic and Molecular Pathology - Metabolic Bone Pathology

Selected Publications
	Vaira, S., Johnson, T., Hirbe, A.C., Alhawagri, M., Anwisye, I., Sammut, B., O’Neal, J., Zou, W., Weilbaecher, K.N., Faccio, R., and Novack, D.V.. RelB is the NF-kB subunit downstream of NIK responsible for osteoclast differentiation.. . Proc. Natl. Acad. Sci. 105:3897-3902., 2008
	Ramanadham, S., Yarasheski, K.E., Silva, M.J., Wohltmann, M., Novack, D.V., Christiansen, B., Tu, X., Zhang, S.,Lei, X., and John Turk. Age-Related Changes in Bone Morphology are Accelerated in Group VIA Phospholipase A2 (iPLA2B)1-Null Mice. . Am. J. Pathol 172:868-81., 2008
	Whyte M.P., McAlister W.H., Novack D.V., Clements K.L., Schoenecker P.L., Wenkert D.. Bisphosphonate-Induced Osteopetrosis: Novel Bone Modeling Defects, Metaphyseal Osteopenia, and Osteosclerosis Fractures After Drug Exposure Ceases.. . J. Bone Miner Res 23:1698-1707, 2008
	Vaira, S., Alhawagri, M., Anwisye, I., Kitaura, H., Faccio, R., and Novack, D.V.. RANKL activates an apoptotic JNK pathway opposed by RelA/p65.. J. Clin. Invest. 118:2088-2097., 2008
	Cremasco, V., Graham, D.B., Novack, D.V., Swat, W. and Faccio, R. Vav/PLCg2 pathway controls neutrophil-dependent inflammatory response during rheumatoid arthritis. Arthritis and Rheumatism 58:2712-2722., 2008
	Li, X., Qin, L., Bergenstock, M., Bevelock, L.M., Novack, D.V., and Partridge, N.C.. Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts.. J Biol Chem 282(45):33098-106, 2007 Abstract
	Matsuzaki, H., Wohl, G.R., Novack, D.V., Lynch, J.A., and Silva, M.J.. Damaging Fatigue Loading Stimulates Increases in Periosteal Vascularity at Sites of Bone Formation in the Rat Ulna.. Calcif Tissue Int 80:391-9., 2007 Abstract
	Mao, D., Epple, H., Uthgenannt, B., Novack, D.V., and Faccio, R. PLCg2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.. J Clin Invest 116: 2869-2879, 2006
	Armamento-Villareal, R., Napoli, N., Panwar, V., and Novack, D.. Suppressed bone turnover during alendronate therapy for high-turnover osteoporosis. N Engl J Med 355: 2048-2050., 2006
	Kitaura H, Sands MS, Aya K, Zhou P, Hirayama T, Uthgenannt B, Wei S, Takeshita S, Novack DV, Silva M. NIK controls lymphocyte and osteoclast activities in inflammatory arthritis. J. Clin. Invest. 115: 3418-3427, 2005
	Zhao, H, Kitaura, H, Sands, MS, Ross,FP, Teitelbaum,SL, Novack,DV. Critical role of B3 integrin in experimental post-menopausal osteoporosis. J.Bone and Mineral Research, 20: 2116-2123, 2005
	Choi ET, Khan MF, Leidenfrost BA, Collins ET, Boc KP, Villa BR, Novack DV, Parks WC, and Abendschein. â3 integrin mediates smooth muscle cell accumulation in neointima arfter carotid ligation in mice. Circulation; 109: 1564-9, 2004
	Weng S, Zemany L, Standley KN, Novack DV, La Regina M, Bernal-Mizrachi C, Coleman T, Semenkovich CF. â3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Proc Natl Acad Sci U S A 100:6730-5, 2003
	Faccio R, Novack DV, Zallone A, Ross FP, Teitelbaum SL. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by â3 integrin. J Cell Biol. 162: 499-509, 2003
	Novack DV, Yin L, Hagen-Stapleton A, Schreiber RD, Goeddel DV, Ross FP, Teitelbaum SL. The IêB function of NF-êB2 p100 controls stimulated osteoclastogenesis. J Exp. Med. 198; 771-781, 2003
	Novack DV, Feng X, Faccio R, Ory DS, Aya K, Boyer MI, McHugh KP, Ross FP, and Teitelbaum SL. A Glanzmanns mutation in â3 integrin specifically impairs osteoclast function. J Clin Invest 107: 1137-1144, 2001
	Cenci S, Weitemann MN, Roggia C, Namba N, Novack D, Woodring J, and Pacifici R. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-á. J Clin Invest 106: 1203-1204, Abstract