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Professor, Pathology and Immunology Room 3720, West Building Office: (314) 362-7426 E-mail: aperry@wustl.edu Pub Med Search

Research

As a diagnostic neuropathologist with a focus on CNS tumors, I am primarily involved in translational research with the primary goal of developing new diagnostic and prognostic markers, which can be utilized in the clinical management of brain tumor patients. In order to achieve this goal, we have applied immunohistochemical, molecular cytogenetic, and genomic screening techniques primarily towards the study of gliomas, meningiomas, and primitive pediatric malignancies. I have been particularly interested in improved classification and grading schemes as well as the identification of molecular genetic markers associated with tumorigenesis, malignant progression, and/or biologic behavior. I collaborate with a number of clinical and scientific researchers both within and outside Washington University and it is our hope that the markers we identify will improve patient management and lead to the development of novel therapeutic approaches. I also maintain a private consultation service for difficult surgical neuropathology cases obtained from the U.S. and abroad, particularly brain tumors (see link to Neuropathology Consult webpage above).

Editorial Responsibilities
	2007 - Present	Editor-in-chief	Brain Pathology
	2005 - Present	Editorial Board	Human Pathology
	2005 - Present	Editorial Board	Journal of Neuropathology and Experimental Neurology
	2005 - 2007	Editorial Board	Acta Neuropathologica
	2004 - Present	Editorial Board	Journal of Neuro-Oncology
	2000 - Present	Editorial Board	Advances in Anatomic Pathology

Service to the Department
	Present	Medical Director, Fluorescence In-Situ Hybridiation (FISH) Laboratory in Anatomic Pathology

Service to the University
	2000 - Present	Neuropathology Course Director, Second Year Washington University Medical School "Diseases of the Nervous System" Course
	Present	Research Member, Alvin J. Siteman Cancer Center, Cancer Genetics Research Program

Diagnostic Expertise
	Brain tumor diagnosis, genetic characterization, and biomarker development

Clinical Interest
	Neuropathology - Neuropathology

Selected Publications
	Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB. Blocking CXCR4-mediated cAMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15; 67:651-658, 2007 Abstract
	Sharma MK, Mansur DB, Reifenberger G, Perry A, Leonard JR, Aldape KD, Albin MG, Emnett RJ, Loeser S, Watson MA, Nagarajan R, Gutmann DH. Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Res. 2007 Feb 1;67:890-900, 2007 Abstract
	Worley LA, Onken MD, Person E, Robirds D, Branson J, Char DH, Perry A, Harbour JW. Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma. Clin Cancer Res. 2007 Mar 1;13(5):1466-71, 2007 Abstract
	Martin DT, Gendron RL, Jarzembowski JA, Perry A, Collins MH, Pushpanathan C, Miskiewicz E, Castle VP, Paradis H. Tubedown expression correlates with the differentiation status and aggressiveness of neuroblastic tumors. Clin Cancer Res. 2007 Mar 1;13:1480-7, 2007 Abstract
	Miller CR, Perry A. Glioblastoma: Morphologic and molecular genetic diversity. rch Pathol Lab Med. 2007 Mar;131:397-406, 2007 Abstract
	Rodriguez FJ, Scheithauer BW, Robbins PD, Burger PC, Hessler RB, Perry A, Abell-Aleff PC, Mierau GW. Ependymomas with neuronal differentiation: A morphologic and immunohistochemical spectrum. Acta Neuropathol. Mar;113(3):313-24, 2007 Abstract
	Rajaram V, Knezevich S, Bove KE, Perry A, Pfeifer JD. DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation. Genes Chrom Cancer. 2007 May;46:508-13, 2007 Abstract
	Aldape K, Burger P, Perry A.. Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma. Arch Pathol Lab Med. 2007 Feb;131(2):242-51, 2007 Abstract
	Chicoine MR, Zahner M, Won EK, Kalra RR, Kitamura T, Perry A, Higashikubo R. The in vivo antitumoral effects of lipopolysaccharide against glioblastoma are mediated in part by Toll-like receptor-4. Neurosurgery. 2007 Feb; 60:372-81, 2007 Abstract
	Brat DJ, Shehata B, Castellano-Sanchez AA, Hawkins C, Yost RB, Greco C, Mazewski C, Janss A, Ohgaki H, Perry A. Congenital glioblastoma: A clinicopathologic and genetic analysis. Brain Pathol 17:276-81, 2007 Abstract
	Miller CR, Dunham CP, Scheithauer BW, Perry A.. Significance of necrosis in grading of oligodendroglial neoplasms: A clinicopathological and genetic study of newly-diagnosed high-grade gliomas. J Clin Oncol. 2006 Dec 1;24:5419-26, 2006 Abstract
	Riemenschneider MJ, Perry, A, Reifenberger G. Histological classification and molecular genetics of meningiomas. Lancet Neurol. 2006 Dec;5:1045-54, 2006 Abstract
	Tu Ph, Giannini C, Judkins AR, Schwalb JM, Burack R, O’Neill BP, Yachnis AT, Burger PC, Scheithauer BW, Perry A. Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: A primary low-grade CNS lymphoma that mimics meningioma. J Clin Oncol 23:5718-27, 2005 Abstract
	Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Res 65:7121-26, 2005 Abstract
	Perry A, Kurtkaya-Yapicier O, Scheithauer BW, Robinson S, Prayson RA, Kleinschmidt-DeMasters BK, Ste. Insights into meningioangiomatosis with and without meningioma: A clinicopathologic and genetic series of 24 cases with review of the literature. Brain Pathol 15:55-65, 2005 Abstract
	Rajaram V, Brat DJ, Perry A. Anaplastic meningioma vs. meningeal hemangiopericytoma: Immunohistochemical and genetic markers. Hum Pathol 35:1413-1418, 2004 Abstract
	Perry A, Aldape KD, George DH, Burger PC. Small cell astrocytoma: An aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma. Cancer 101:2318-2326, 2004 Abstract
	Fallon KB, Palmer CA, Roth KA, Carpenter M, Banerjee R, Forsyth P, Perry A. Prognostic value of 1p, 19q, 9p, 10q, and EGFR FISH analyses in recurrent oligodendrogliomas. J Neuropathol Exp Neurol 63:314-322, 2004 Abstract
	Brat DJ, Seiferheld WF, Perry A, Hammond EH, Murray KJ, Schulsinger AR, Mehta MP, Curran WJ. Radiation Therapy Oncology Group. Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using FISH on tissue microarrays from RTOG trials. Neuro-oncol 6:96-103, 2004 Abstract
	Rajaram V, Leuthardt EC, Singh PK, Ojemann JG, Brat DJ, Prayson RA, Perry A. 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases. Mod Pathol 17:9-14, 2004 Abstract
	Bajenaru ML, Hernandez MR, Perry A, Zhu Y, Parada LF, Garbow JR, Gutmann DH. Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res 63:8573-8577, 2003 Abstract
	Gutmann DH, James CD, Poyhonen M, Louis DN, Ferner R, Guha A, Hariharan S, Viskochil D, Perry A. Molecular analysis of astrocytomas presenting after age ten in individuals with NF1. Neurology 61:1397-1400, 2003 Abstract
	Fuller CE, Schmidt RE, Roth KA, Burger PC, Scheithauer BW, Banerjee R, Trinkaus K, Lytle R, Perry A. Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial / astrocytic features. J Neuropathol Exp Neurol 62:1118-1128, 2003 Abstract
	Perry A, Dehner LP. Meningeal tumors of childhood and infancy. An update and literature review. Brain Pathol 13:386-408, 2003 Abstract
	Perry A. Pathology of low-grade gliomas. An update of emerging concepts. Neuro-oncol 5:168-178, 2003 Abstract
	Perry A, Fuller CE, Banerjee R, Brat DJ, Scheithauer BW. Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics. Front Biosci 8:a1-9, 2003 Abstract
	Watson MA, Gutmann DH, Peterson K, Chicoine MR, Kleinschmidt-DeMasters BK, Brown HG, Perry A. Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays. Am J Pathol 161:665-672, 2002 Abstract
	Perry A, Kunz SN, Fuller CE, Banerjee R, Marley EF, Liapis H, Watson MA, Gutmann DH. Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. J Neuropathol Exp Neurol 61:702-709, 2002 Abstract
	Perry A, Banerjee R, Lohse CM, Kleinschmidt-DeMasters BK, Scheithauer BW. A role for chromosome 9p21 deletions in the malignant progression of meningiomas and the prognosis of anaplastic meningiomas. Brain Pathol 12:183-190, 2002 Abstract
	Perry A, Scheithauer BW, Macaulay RJ, Raffel C, Roth KA, Kros JM. Oligodendrogliomas with neurocytic differentiation. A report of four cases with diagnostic and histogenetic implications. J Neuropathol Exp Neurol 61:947-955, 2002 Abstract
	Perry A. Medulloblastomas with Favorable vs. Unfavorable Histology. How Many Small Blue Cell Tumor Types are there in the Brain?. Adv Anat Pathol 9:345-350, 2002 Abstract
	Fuller CE, Perry A. Fluorescence in situ hybridization (FISH) in diagnostic and investigative neuropathology. Brain Pathol 12:67-86, 2002 Abstract